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. . . .. 23 (4)/2014 ò ˲ʲ Ͳֲ H.O. Yeromina, S.G. Isaev, N.Yu. Sheveliova, Z.G. Yeromina Synthesis, structure and pharmacological activity of 6,9-diamino-2-ethoxyacridinium 6-nitro-n-phenylanthranilates National University of Pharmacy Introduction. A special place among acridine derivatives is occupied by substituted 9-aminoacridine and their salts with aromatic acids.

Materials and methods. Synthesis of the salts was carried out at the Department of Medicinal Chemistry of NPhaU. The biological screening was carried out at the Department of Microbiology, Virusology and Immunology of NPhaU.

Results. 9 salts were synthesized. The structure and individuality of the compounds were confirmed by IR-spectral, element and chromatographic analysis. It was established that the synthesized compounds had bacteriostatic, fungistatic, diuretic, antiinflammatory and analgesic activities. According to the classification by K.K. Sydorov these salts belong to low toxic compounds.

Conclusion. The conducted research are indicative of the prospects of search for new biologically active compounds based on derivatives of anthranilic acid.

Key words: synthesis, 6,9-diamino-2-ethoxyacridinium, N-phenylanthranilic acid, pharmacological activity.

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